4-(3-甲氧基苯基)环己酮合成路线 （共 7 条）
反应条件
toluene-4-sulfonic acid in acetone
T=60°C;
参考文献
Chu, Xin-Jie; Bartkovitz, David; Danho, Waleed; Swistok, Joseph; Cheung, Adrian Wai-Hing; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Qi, Lida; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4910 - 4914
反应条件
1: TsOH / benzene / Heating
2: H2 / Pd/C / ethyl acetate / 3 h
3: TsOH / acetone / 60 °C
View Scheme
参考文献
Chu, Xin-Jie; Bartkovitz, David; Danho, Waleed; Swistok, Joseph; Cheung, Adrian Wai-Hing; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Qi, Lida; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4910 - 4914
反应条件
1: tetrahydrofuran / 3 h / 10 - 20 °C
2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C
View Scheme
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
反应条件
1: H2 / Pd/C / ethyl acetate / 3 h
2: TsOH / acetone / 60 °C
View Scheme
参考文献
Chu, Xin-Jie; Bartkovitz, David; Danho, Waleed; Swistok, Joseph; Cheung, Adrian Wai-Hing; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Qi, Lida; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4910 - 4914
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux
1.2: 20 °C / |Reflux
2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr
4.1: sulfuric acid / tetrahydrofuran; water / 1.5 h
View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026,4
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate
T=20°C; 16 h;
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
反应条件
(i) CF3CO2H, (ii) H2, Pd-C; Multistep reaction;
参考文献
Lednicer,D. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, # 12 p. 1239 - 1243
