2-丙酮基-1,1-二氧代-1,2-苯并噻唑-3-酮合成路线 （共 10 条）
反应条件
1: sodium ethanolate / 0.08 h / 20 °C 2: sodium hydroxide / water / 0.5 h / 20 °C View Scheme
参考文献
Aslam, Sana; Zaib, Sumera; Ahmad, Matloob; Gardiner, John M.; Ahmad, Aqeel; Hameed, Abdul; Furtmann, Norbert; Guetschow, Michael; Bajorath, Juergen; Iqbal, Jamshed
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 106 - 117
参考文献
Eckenroth; Klein
Chemische Berichte, 1896 , vol. 29, p. 330
Chem. Zentralbl., 1897 , vol. 68, # I p. 235
参考文献
Eckenroth; Klein
Chemische Berichte, 1896 , vol. 29, p. 330
Chem. Zentralbl., 1897 , vol. 68, # I p. 235
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 48 h;
参考文献
D'Ascenzio, Melissa; Carradori, Simone; De Monte, Celeste; Secci, Daniela; Ceruso, Mariangela; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1821 - 1831
反应条件
in N,N-dimethyl-formamide
T=110°C; 3 h; Inert atmosphere;
参考文献
Aslam, Sana; Zaib, Sumera; Ahmad, Matloob; Gardiner, John M.; Ahmad, Aqeel; Hameed, Abdul; Furtmann, Norbert; Guetschow, Michael; Bajorath, Juergen; Iqbal, Jamshed
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 106 - 117
反应条件
in N,N-dimethyl-formamide
T=125°C; 2 h;
参考文献
Chapman Jr.; Cocolas; Hall
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 243 - 246
反应条件
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide in decane; ethyl acetate
T=130°C; 3 h; Sealed tube;
参考文献
Lv, Yunhe; Li, Yan; Xiong, Tao; Lu, Yu; Liu, Qun; Zhang, Qian
Chemical Communications, 2014 , vol. 50, # 18 p. 2367 - 2369
参考文献
Eckenroth; Klein
Chemische Berichte, 1896 , vol. 29, p. 330
Chem. Zentralbl., 1897 , vol. 68, # I p. 235
反应条件
1: With ethanol; sodium ethanolate
T=55°C; 0.5 h;
2: With hydrogenchloride
T=20°C; 0.5 h;
参考文献
Brooke, Edward W.; Davies, Stephen G.; Mulvaney, Andrew W.; Okada, Minoru; Pompeo, Frederique; Sim, Edith; Vickers, Richard J.; Westwood, Isaac M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2527 - 2530
参考文献
Eckenroth; Klein
Chemische Berichte, 1896 , vol. 29, p. 330
Chem. Zentralbl., 1897 , vol. 68, # I p. 235
