1-[双(三氟甲烷磺酰基)甲基]-2,3,4,5,6-五氟苯合成路线 （共 2 条）
反应条件
1: (2,3,4,5,6-pentafluorophenyl)methyl trifluoromethyl sulfone With tert.-butyl lithium in diethyl ether
T=-78°C; 0.5 h;
2: trifluoromethylsulfonic anhydride in diethyl ether
T=-78 - 20°C; 1 h;
参考文献
Ishihara, Kazuaki; Hasegawa, Aiko; Yamamoto, Hisashi
Angewandte Chemie - International Edition, 2001 , vol. 40, # 21 p. 4077 - 4079
反应条件
1.1: 89 percent / propiononitrile / Heating
2.1: tBuLi / diethyl ether; hexane / 0.33 h / -78 °C
2.2: diethyl ether; hexane / 1 h / -78 - 20 °C
View Scheme
参考文献
Hasegawa, Aiko; Ishikawa, Takuo; Ishihara, Kazuaki; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 8 p. 1401 - 1410
