2-(氯甲氧基)乙酸乙酯合成路线 （共 31 条）
反应条件
zinc(II) chloride in diethyl ether
T=19 - 27°C; 5.33333 h;
参考文献
GILEAD SCIENCES, INC.
Patent: WO2005/66189 A1, 2005 ;
Location in patent: Page/Page column 71 ;
参考文献
Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic; Rega Stichting v.z.w.
Patent: US5650510 A1, 1997 ;
反应条件
4 A molecular sieve; silver carbonate in dichloromethane
Title compound not separated from byproducts;
参考文献
Aitken, David J.; Rees, Lilias; Suckling, Colin J.; Wood, Hamish C. S.
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3417 - 3420
反应条件
sodium hydroxide; 4 A molecular sieve; silver carbonate
1.) CH2Cl2, room temp. 2.) reflux, 2 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Aitken, David J.; Rees, Lilias; Suckling, Colin J.; Wood, Hamish C. S.
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3417 - 3420
反应条件
sodium hydroxide; 4 A molecular sieve; silver carbonate
1) CH2Cl2, room temperature, 24 h, 2) MeOH, H2O, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Aitken, David J.; Alijah, Renate; Onyiriuka, Samuel O.; Suckling, Colin J.; Wood, Hamish C. S.; Zhu, Limin
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 5 p. 597 - 608
反应条件
T=110°C; 3 h; Inert atmosphere;
参考文献
Manvar, Atul; Shah, Anamik
Tetrahedron, 2013 , vol. 69, # 2 p. 680 - 691
参考文献
Hockova, Dana; Holy, Antonin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 5064 - 5073
参考文献
Karpeiskii, M. Ya.; Mikhailov, S. M.; Tsieminya, A. S.; Ziderman, A. A.; Kravchenko, I. M.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 11 p. 1176 - 1179
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 11 p. 1541 - 1544
反应条件
in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Colla; Busson; De Clercq; Vanderhaeghe
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 6 p. 569 - 576
反应条件
sodium methylate in N,N-dimethyl-formamide
1.) 35 deg C, 10 min 2.) room temp. - 50 deg C, 2 h;
参考文献
Foye; Kauffman; Kim
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 3 p. 497 - 501
