2-(氯甲基)-6-甲氧基吡啶合成路线 （共 5 条）
反应条件
thionyl chloride in monofluorodichloromethane
T=0 - 50°C; 2 h; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew
Patent: WO2012/40230 A1, 2012 ;
Location in patent: Page/Page column 87-88 ;
WO 2012/040230 A1
反应条件
1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C
2: thionyl chloride / monofluorodichloromethane / 2 h / 0 - 50 °C / Inert atmosphere
View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew
Patent: WO2012/40230 A1, 2012 ;
WO 2012/040230 A1
反应条件
1: N,N-dimethyl-formamide / 16 h / 20 - 100 °C
2: thionyl chloride / 16 h / 70 °C
3: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C
4: thionyl chloride / monofluorodichloromethane / 2 h / 0 - 50 °C / Inert atmosphere
View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew
Patent: WO2012/40230 A1, 2012 ;
WO 2012/040230 A1
反应条件
1: thionyl chloride / 16 h / 70 °C
2: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C
3: thionyl chloride / monofluorodichloromethane / 2 h / 0 - 50 °C / Inert atmosphere
View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew
Patent: WO2012/40230 A1, 2012 ;
WO 2012/040230 A1
反应条件
1: silver carbonate / chloroform / 26 h / 60 °C
2: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C
3: thionyl chloride / 2 h / 20 °C
View Scheme
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
