4-氨基-5-氟-3-[5-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基]喹啉-2(1H)-酮合成路线 （共 6 条）
反应条件
potassium tert-butylate in tetrahydrofuran; toluene T=17 - 30°C; 2 h;
参考文献
NOVARTIS AG
Patent: WO2006/125130 A1, 2006 ;
Location in patent: Page/Page column 70-71 ;
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
参考文献
Antonios-McCrea, William R.; Frazier, Kelly A.; Jazan, Elisa M.; Machajewski, Timothy D.; McBride, Christopher M.; Pecchi, Sabina; Renhowe, Paul A.; Shafer, Cynthia M.; Taylor, Clarke
Tetrahedron Letters, 2006 , vol. 47, # 5 p. 657 - 660
反应条件
1: 99 percent / ethanol / 40 h / 97 °C 2: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C 3: 1.98 kg / aq. ethanol / 2 h 4: 85.4 percent / KOt-Bu / tetrahydrofuran; toluene / 2 h / 17 - 30 °C View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
1: 99 percent / ethanol / 40 h / 97 °C 2: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C 3: 1.98 kg / aq. ethanol / 2 h 4: 85.4 percent / KOt-Bu / tetrahydrofuran; toluene / 2 h / 17 - 30 °C View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
1: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C 2: 1.98 kg / aq. ethanol / 2 h 3: 85.4 percent / KOt-Bu / tetrahydrofuran; toluene / 2 h / 17 - 30 °C View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
1: 1.98 kg / aq. ethanol / 2 h 2: 85.4 percent / KOt-Bu / tetrahydrofuran; toluene / 2 h / 17 - 30 °C View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
