2-溴-3-(丁基-3-烯氧基)吡啶合成路线 （共 5 条）
反应条件
1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / |Inert atmosphere 2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C 2.2: 12 h / -78 - 20 °C View Scheme
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;
反应条件
tetraethylammonium chloride; potassium acetate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=105°C; Intramolecular Heck cyclization;
参考文献
WO2008/100459 A1, ;
Page/Page column 105-106 ;
WO 2008/100459 A1
反应条件
potassium acetate; triphenylphosphine; palladium diacetate in argon
参考文献
US2004/19058 A1, ;
US 20040019058 A1
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0°C; Mitsunobu reaction; Heating / reflux;
参考文献
SCHERING CORPORATION; BOYCE, Christopher W; CHAO, Jianhua; MCCORMICK, Kevin D.
Patent: WO2010/33495 A2, 2010 ;
Location in patent: Page/Page column 76 ;
反应条件
NaHCO3; diisopropyl (E)-diazene-1,2-dicarboxylate; triphenylphosphine in tetrahydrofuran; ethyl acetate
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
