2,3-二氢-4H-吡喃并[3,2-B]吡啶-4-酮合成路线 （共 7 条）
反应条件
sodium periodate in water T=20°C; 2 h;
参考文献
SCHERING CORPORATION; BOYCE, Christopher W; CHAO, Jianhua; MCCORMICK, Kevin D.
Patent: WO2010/33495 A2, 2010 ;
Location in patent: Page/Page column 76; 77-78 ;
反应条件
1: With sodium hydrogencarbonate; ozone in methanol; chloroform T=-78°C; 16 h; 2: With dimethylsulfide in methanol; chloroform T=-78 - 20°C; 12 h;
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;
Location in patent: Paragraph 0485 ;
反应条件
1.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 17.5 h / 0 - 50 °C / |Inert atmosphere 2.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / |Inert atmosphere 3.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C 3.2: 12 h / -78 - 20 °C View Scheme
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;
反应条件
1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / |Inert atmosphere 2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C 2.2: 12 h / -78 - 20 °C View Scheme
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;
反应条件
1: With sodium tetrahydroborate in methanol T=20°C; 2: With methanol; water 0.5 h;
参考文献
SCHERING CORPORATION; BOYCE, Christopher W; CHAO, Jianhua; MCCORMICK, Kevin D.
Patent: WO2010/33495 A2, 2010 ;
Location in patent: Page/Page column 76; 78 ;
反应条件
1: 924 mg / hydroxylamine hydrochloride / methanol / 20 °C
2: 86 percent / ammonium hydroxide; ammonium acetate; zinc / ethanol / 17 h / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; TRIESELMANN, Thomas; TIELMANN, Patrick; SCHEUERER, Stefan; HOBBIE, Silke (Marie Katrin)
Patent: WO2010/70032 A1, 2010 ;
Location in patent: Page/Page column 115 ;
WO 2010/070032 A1
反应条件
1: With sodium tetrahydroborate in methanol
T=20°C;
2: With methanol; water
0.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/100459 A1, 2008 ;
Location in patent: Page/Page column 105; 107 ;
WO 2008/100459 A1
