3-氨基-5-溴-1H-吡唑并[3,4-B]吡啶合成路线 （共 8 条）
反应条件
hydrazine in ethanol T=170°C; 0.166667 h; Microwave irradiation;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/59219 A1, 2007 ;
Location in patent: Page/Page column 54-55 ;
WO 2007/059219 A1
反应条件
hydrazine T=20 - 100°C; 3 h;
参考文献
PIERRE FABRE MEDICAMENT; Sokoloff, Pierre; Cachoux, Frédéric
Patent: EP2689778 A1, 2014 ;
Location in patent: Paragraph 0186 ;
反应条件
1.1: sodium / 0.17 h / 20 °C 1.2: 0 - 25 °C 1.3: 0 °C 2.1: sodium acetate; bromine / acetic acid / 0 - 70 °C 3.1: hydrazine / 3 h / 20 - 100 °C View Scheme
参考文献
PIERRE FABRE MEDICAMENT; Sokoloff, Pierre; Cachoux, Frédéric
Patent: EP2689778 A1, 2014 ;
Title/Abstract Full Text Show Details
PIERRE FABRE MEDICAMENT; Kruczynski, Anna; Creancier, Laurent; Kaloun, El Bachir; Bedjeguelal, Karim; Rabot, Rémi
Patent: EP2689779 A1, 2014 ;
反应条件
1: sodium acetate; bromine / acetic acid / 0 - 70 °C 2: hydrazine / 3 h / 20 - 100 °C View Scheme
参考文献
PIERRE FABRE MEDICAMENT; Sokoloff, Pierre; Cachoux, Frédéric
Patent: EP2689778 A1, 2014 ;
Title/Abstract Full Text Show Details
PIERRE FABRE MEDICAMENT; Kruczynski, Anna; Creancier, Laurent; Kaloun, El Bachir; Bedjeguelal, Karim; Rabot, Rémi
Patent: EP2689779 A1, 2014 ;
反应条件
1: 59 percent / Br2; AcOH 2: 94 percent / POCl3; PCl5 / Heating 3: 75 percent / N2H4*H2O / ethanol / Heating View Scheme
参考文献
Huart, Anne-Sophie; Saxty, Barbara; Merritt, Andy; Nekulova, Marta; Lewis, Stephen; Huang, Yide; Vojtesek, Borivoj; Kettleborough, Catherine; Hupp, Ted R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5578 - 5585
反应条件
1: 94 percent / POCl3; PCl5 / Heating 2: 75 percent / N2H4*H2O / ethanol / Heating View Scheme
参考文献
Huart, Anne-Sophie; Saxty, Barbara; Merritt, Andy; Nekulova, Marta; Lewis, Stephen; Huang, Yide; Vojtesek, Borivoj; Kettleborough, Catherine; Hupp, Ted R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5578 - 5585
反应条件
1: bromine; acetic acid; sodium carbonate / 2 h / 20 °C 2: hydrogenchloride; sodium nitrite / water / -5 - 20 °C 3: hydrazine hydrate / butan-1-ol / 80 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita
Patent: WO2013/42035 A1, 2013 ;
反应条件
1: hydrogenchloride; sodium nitrite / water / -5 - 20 °C 2: hydrazine hydrate / butan-1-ol / 80 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita
Patent: WO2013/42035 A1, 2013 ;
