3-氯-2,6-二氟-4-吡啶胺合成路线 （共 4 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol
P=2585.74 Torr; 18 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 11 ;
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 57 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
zinc
8 h; Product distribution; Further Variations:Reagentstime;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
反应条件
1: 76.4 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 82 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
