3-(1,3-苯并二氧戊环-5-基)-2-甲基丙烯酸合成路线 （共 13 条）
参考文献
Eijkman
Chemische Berichte, 1889 , vol. 22, p. 2749
参考文献
Societe Civile Bioproject
Patent: US5612371 A1, 1997 ;
反应条件
potassium hydroxide in methanol
T=20°C; 2 h;
参考文献
Das, Biswanath; Banerjee, Joydeep; Chowdhury, Nikhil; Majhi, Anjoy
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1725 - 1727
反应条件
water; triphenylphosphine; sodium hydroxide in acetonitrile
T=100°C; 1 h; Microwave irradiation; regioselective reaction;
参考文献
Meier, Lidiane; Ferreira, Misael; Sa, Marcus M.
Heteroatom Chemistry, 2012 , vol. 23, # 2 p. 179 - 186
反应条件
1: I2; NaBH4 / tetrahydrofuran / 20 °C
2: KOH / methanol / 2 h / 20 °C
View Scheme
参考文献
Das, Biswanath; Banerjee, Joydeep; Chowdhury, Nikhil; Majhi, Anjoy
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1725 - 1727
反应条件
2: lithium bromide / Acidic conditions
3: water; triphenylphosphine; sodium hydroxide / acetonitrile / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Meier, Lidiane; Ferreira, Misael; Sa, Marcus M.
Heteroatom Chemistry, 2012 , vol. 23, # 2 p. 179 - 186
反应条件
1: lithium bromide / Acidic conditions
2: water; triphenylphosphine; sodium hydroxide / acetonitrile / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Meier, Lidiane; Ferreira, Misael; Sa, Marcus M.
Heteroatom Chemistry, 2012 , vol. 23, # 2 p. 179 - 186
反应条件
water; sodium hydroxide
T=100°C; 0.5 h; Microwave irradiation; regioselective reaction;
参考文献
Meier, Lidiane; Ferreira, Misael; Sa, Marcus M.
Heteroatom Chemistry, 2012 , vol. 23, # 2 p. 179 - 186
反应条件
propionic acid sodium salt
参考文献
Moureu
Bulletin de la Societe Chimique de France, 1896 , vol. <3> 15, p. 655
Annales de Chimie (Cachan, France), 1899 , vol. <7> 18, p. 104
Full Text Show Details
Eijkman
Chemische Berichte, 1889 , vol. 22, p. 2749
Full Text Show Details
Lorenz
Chemische Berichte, 1880 , vol. 13, p. 758
反应条件
n-butyllithium
1.) hexane, THF, -60 deg C, 30 min, 2.) -60 deg, 1 h; -60 deg C --> room temp.; room temp., 3 h; Yield given. Multistep reaction;
参考文献
Coutrot, Philippe; Ghribi, Abdellaziz
Synthesis, 1986 , # 9 p. 790 - 792
