5-(羟基甲基)喹啉-8-醇合成路线 （共 5 条）
反应条件
sodium hydride 1.) DMF, 45 min, 2.) DMF, 4 h; Yield given. Multistep reaction;
参考文献
University of Florida
Patent: US4894219 A1, 1990 ;
US 4894219 A
反应条件
sodium hydride in N,N-dimethyl-formamide Alkylation; 16 h;
参考文献
Soulounganga; Gerardin; Loubinoux
Synthetic Communications, 2000 , vol. 30, # 11 p. 1927 - 1935
反应条件
sodium hydroxide; water T=120°C;
参考文献
Zinner; Fiedler
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 493,502
反应条件
1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h 2: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature 3: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 4: 1.98 g / Ac2O / 2.5 h / 50 °C 5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
反应条件
thionyl chloride T=20°C; 6 h;
参考文献
Li, Lihua; Xu, Bing
Tetrahedron, 2008 , vol. 64, # 49 p. 10986 - 10995
