6-甲基-4-苯基-2-色满酮合成路线 （共 24 条）
反应条件
1: potassium carbonate / acetone / 3 h / |Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 25 - 35 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C
4: N,N-dimethyl-formamide / 16 h / 60 - 70 °C / 2250.23 Torr / |Autoclave; |Inert atmosphere
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参考文献
Srinivas, Keesari; Srinivasan, Neti; Reddy, Kikkuru Srirami; Ramakrishna, Muddasani; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Kumari, Routhu Lalitha; Venkataraman, Sundaram; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2005 , vol. 9, # 3 p. 314 - 318
反应条件
1: potassium carbonate / acetone / 3 h / |Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 25 - 35 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C
4: N,N-dimethyl-formamide / 16 h / 60 - 70 °C / 2250.23 Torr / |Autoclave; |Inert atmosphere
5: hydrogen / methanol / 5 h / 25 - 35 °C / 2250.23 Torr / |Autoclave
View Scheme
参考文献
Srinivas, Keesari; Srinivasan, Neti; Reddy, Kikkuru Srirami; Ramakrishna, Muddasani; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Kumari, Routhu Lalitha; Venkataraman, Sundaram; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2005 , vol. 9, # 3 p. 314 - 318
反应条件
1: potassium carbonate / methanol / 10 h / 55 - 60 °C
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -5 - 5 °C / Inert atmosphere
3: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere
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参考文献
PHARMATHEN S.A.
Patent: US2012/41235 A1, 2012 ;
反应条件
1: potassium carbonate / acetone / 3 h / |Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 25 - 35 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C
4: acetonitrile / 12 h / 35 - 40 °C
5: hydrogen / methanol / 25 - 30 °C / 2625.26 Torr / |Autoclave
View Scheme
参考文献
Srinivas, Keesari; Srinivasan, Neti; Reddy, Kikkuru Srirami; Ramakrishna, Muddasani; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Kumari, Routhu Lalitha; Venkataraman, Sundaram; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2005 , vol. 9, # 3 p. 314 - 318
