N-(4-乙酰基-3-羟基苯基)乙酰胺合成路线 （共 15 条）
反应条件
hydrogenchloride in water T=50°C; 3 h;
参考文献
Hu, Yun; Yang, Yaqi; Yu, Yanjun; Wen, Gesi; Shang, Nana; Zhuang, Wei; Lu, Dihan; Zhou, Binhua; Liang, Baoxia; Yue, Xin; Li, Feng; Du, Jun; Bu, Xianzhang
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6033 - 6053
反应条件
1: With AlCl3, aluminium chloride in dichloromethane; chlorobenzene
T=80 - 132°C; 4.83333 h;
2: With water in chlorobenzene
T=0°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/88438 A2, 2007 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With AlCl3, aluminium chloride
T=75 - 95°C; Cautiously heating;
2: T=20°C;
3: With water
more than 3 stages;
参考文献
VERNALIS (CAMBRIDGE) LIMITED; CANCER RESEARCH TECHNOLOGY LTD; THE INSTITUTE OF CANCER RESEARCH
Patent: WO2004/56782 A1, 2004 ;
Location in patent: Page 44-45 ;
反应条件
1: 56.49 percent / pyridine / CH2Cl2 / 5 °C
2: 10 percent / aluminium chloride / 2 h / 140 °C
View Scheme
参考文献
Akamanchi; Padmawar; Thatte; Rege; Dahanukar
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 5 p. 323 - 329
反应条件
2: AlCl3; CS2
View Scheme
参考文献
Fel'dman; Simeonow
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 2043,2045; engl. Ausg. S. 2159, 2160
反应条件
aluminium trichloride
Yield given;
参考文献
Nerenberg, Jennie B.; Erb, Jill M.; Bergman, Jeffrey M.; O'Malley, Stacey; Chang, Raymond S. L.; Scott, Ann L.; Broten, Theodore P.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 2 p. 291 - 294
反应条件
carbon disulfide; aluminium trichloride
参考文献
Kasahara
Nippon Kagaku Zasshi, 1955 , vol. 76, p. 535,536
Chem.Abstr., 1957 , p. 17902
Full Text Show Details
Fel'dman; Simeonow
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 2043,2045; engl. Ausg. S. 2159, 2160
反应条件
2: aluminium chloride; carbon disulfide
View Scheme
参考文献
Gibson; Levin
Journal of the Chemical Society, 1931 , p. 2388,2406
反应条件
carbon disulfide; aluminium trichloride
参考文献
Fel'dman; Simeonow
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 2043,2045; engl. Ausg. S. 2159, 2160
反应条件
carbon disulfide; aluminium trichloride
参考文献
Fel'dman; Simeonow
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 2043,2045; engl. Ausg. S. 2159, 2160
