1-(二苯基甲基)-3-亚甲基氮杂啶合成路线 (共 2 条)
反应条件
hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon in ethanol 72 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1942109 A1, 2008 ;
Location in patent: Page/Page column 43 ;
反应条件
1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in dimethyl sulfoxide
T=25°C; 1.25 h;
2: 1-(1,1-diphenylmethyl)azetidin-3-one in dimethyl sulfoxide
T=60°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/141473 A1, 2007 ;
Location in patent: Page/Page column 236 ;
WO 2007/141473 A1