3-(3,5-二氟苯基)丙醇合成路线 （共 3 条）
反应条件
hydrogenchloride; sodium borohydride; triethylamine in tetrahydrofuran; water
参考文献
Davies, David Thomas; Markwell, Roger Edward; Pearson, Neil David
Patent: US2004/53928 A1, 2004 ;
反应条件
1: With diisobutylaluminium hydride in toluene
T=-15 - -8°C; 1 h;
2: With hydrogenchloride in water; toluene
T=40 - 45°C;
参考文献
WYETH
Patent: WO2008/24492 A2, 2008 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: With diisobutylaluminium hydride in dichloromethane
T=-78 - -30°C; Inert atmosphere;
2: With methanol in dichloromethane
Inert atmosphere;
参考文献
Vu, An T.; Cohn, Stephen T.; Zhang, Puwen; Kim, Callain Y.; Mahaney, Paige E.; Bray, Jenifer A.; Johnston, Grace H.; Koury, Elizabeth J.; Cosmi, Scott A.; Deecher, Darlene C.; Smith, Valerie A.; Harrison, James E.; Leventhal, Liza; Whiteside, Garth T.; Kennedy, Jeffrey D.; Trybulski, Eugene J.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2051 - 2062
