1-甲基-1H-吡咯-3-羧酸甲酯合成路线 （共 3 条）
反应条件
sodium hydroxide in methanol Hydrolysis; 6 h; Heating;
参考文献
Mizuno, Akira; Ogata, Atsuto; Kamei, Tomoe; Shibata, Makoto; Shimamoto, Tetsuo; Hayashi, Yasuhiro; Nakanishi, Kyoko; Takiguchi, Chikako; Oka, Naomi; Inomata, Norio
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 623 - 635
反应条件
acetic anhydride in toluene
参考文献
SUNTORY LIMITED
Patent: EP771790 A1, 1997 ;
反应条件
1: 1H-pyrrole-3-carboxylic acid methyl ester With 18-crown-6 ether; potassium tert-butylate in diethyl ether
T=0°C; Metallation; Methylation;
2: methyl iodide in diethyl ether
T=20°C; 1 h;
参考文献
Mizuno, Akira; Ogata, Atsuto; Kamei, Tomoe; Shibata, Makoto; Shimamoto, Tetsuo; Hayashi, Yasuhiro; Nakanishi, Kyoko; Takiguchi, Chikako; Oka, Naomi; Inomata, Norio
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 623 - 635
