4,4-二甲基苯并二氢吡喃合成路线 （共 25 条）
参考文献
The Board of Regents for the Oklahoma Agricultural and Mechanical College acting for and on behalf of Oklahoma State University
Patent: US4826984 A1, 1989 ;
反应条件
bismuth trifluoromethanesulphonate in chloroform
Friedel-Crafts Alkylation; 0.333333 h; Inert atmosphere;
参考文献
Nammalwar, Baskar; Bunce, Richard A.
Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4330 - 4332
反应条件
tetraethylammonium chloride; sodium formate; sodium acetate; palladium diacetate in N,N-dimethyl-formamide
T=85 - 95°C; reductive Heck cyclization;
参考文献
Liu, Pingli; Huang, Liang; Lu, Yuelie; Dilmeghani, Mina; Baum, Jean; Xiang, Tingjian; Adams, Jeff; Tasker, Andrew; Larsen, Rob; Faul, Margaret M.
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2307 - 2310
反应条件
pyridine; thionyl chloride in benzene
2 h; Heating;
参考文献
Knipe, Jay O.; Vasquez, Peter J.; Coward, James K.
Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3202 - 3209
反应条件
1: NaH / dimethylformamide / 20 °C
2: 91 percent / HCOONa; Et4NCl*H2O; NaOAc / Pd(OAc)2 / dimethylformamide / 85 - 95 °C
View Scheme
参考文献
Liu, Pingli; Huang, Liang; Lu, Yuelie; Dilmeghani, Mina; Baum, Jean; Xiang, Tingjian; Adams, Jeff; Tasker, Andrew; Larsen, Rob; Faul, Margaret M.
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2307 - 2310
反应条件
1: NaH / dimethylformamide / 20 °C
2: 91 percent / HCOONa; Et4NCl*H2O; NaOAc / Pd(OAc)2 / dimethylformamide / 85 - 95 °C
View Scheme
参考文献
Liu, Pingli; Huang, Liang; Lu, Yuelie; Dilmeghani, Mina; Baum, Jean; Xiang, Tingjian; Adams, Jeff; Tasker, Andrew; Larsen, Rob; Faul, Margaret M.
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2307 - 2310
反应条件
1: NaH / dimethylformamide / 20 °C
2: 91 percent / HCOONa; Et4NCl*H2O; NaOAc / Pd(OAc)2 / dimethylformamide / 85 - 95 °C
View Scheme
参考文献
Liu, Pingli; Huang, Liang; Lu, Yuelie; Dilmeghani, Mina; Baum, Jean; Xiang, Tingjian; Adams, Jeff; Tasker, Andrew; Larsen, Rob; Faul, Margaret M.
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2307 - 2310
反应条件
1: 1.) dicyclohexylcarbodiimide, cuprous chloride / 1.) 5h, 60 deg C, 2.) 12h, 100 deg C
2: trifluoroacetic acid / 1.) 3 days, room temperature, 2.) EtOH, K2CO3, 15 h
View Scheme
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 4.31 g / pyridine, MeSO2Cl / 1 h / 0 °C
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
para-nitrophenyl mercaptan
参考文献
Knipe, Jay O.; Vasquez, Peter J.; Coward, James K.
Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3202 - 3209
