4,4-二甲基苯并二氢吡喃合成路线 （共 25 条）
反应条件
para-nitrophenyl mercaptan
参考文献
Knipe, Jay O.; Vasquez, Peter J.; Coward, James K.
Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3202 - 3209
反应条件
1: 87.1 percent / p-TsOH / 36 h / Heating
2: 76.4 percent / diethyl ether; tetrahydrofuran / 24 h / Heating
3: 62 percent / AlCl3 / nitromethane / 24 h / Ambient temperature
View Scheme
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
反应条件
1: 76.4 percent / diethyl ether; tetrahydrofuran / 24 h / Heating
2: 62 percent / AlCl3 / nitromethane / 24 h / Ambient temperature
View Scheme
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C to RT, 3 h
2: 77 percent / AlCl3 / CH2Cl2 / 63 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 2 h / Heating
4: 4.31 g / pyridine, MeSO2Cl / 1 h / 0 °C
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
1: 77 percent / AlCl3 / CH2Cl2 / 63 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 2 h / Heating
3: 4.31 g / pyridine, MeSO2Cl / 1 h / 0 °C
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C to RT, 3 h
2: 77 percent / AlCl3 / CH2Cl2 / 63 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 2 h / Heating
4: 4.31 g / pyridine, MeSO2Cl / 1 h / 0 °C
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
tin(IV) chloride
1.) 5 min, 2.) CS2, RT, 17 h; Yield given. Multistep reaction;
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
2: acetate buffer / H2O / 40 °C / other oxyanion buffers; amine buffers
View Scheme
参考文献
Vasquez, Peter J.; Coward, James K.
Journal of the Chemical Society, Chemical Communications, 1982 , # 12 p. 698 - 699
反应条件
acetate buffer
T=40°C; other buffers; Rate constant;
参考文献
Knipe, Jay O.; Vasquez, Peter J.; Coward, James K.
Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3202 - 3209
反应条件
acetate buffer in water
T=40°C; pH 4 to 10;
参考文献
Vasquez, Peter J.; Coward, James K.
Journal of the Chemical Society, Chemical Communications, 1982 , # 12 p. 698 - 699
