4,4-二甲基苯并二氢吡喃合成路线 （共 25 条）
反应条件
1: phenol; concentrated sulfuric acid / 160 °C
2: sodium; amyl alcohol
3: aqueous phosphoric acid / 140 °C
View Scheme
参考文献
Colonge et al.
Bulletin de la Societe Chimique de France, 1957 , p. 776,777
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
反应条件
tin(IV) chloride in carbon disulfide
3 h; Ambient temperature;
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
aluminium trichloride in hydrogenchloride; nitromethane; ethyl acetate
参考文献
AMGEN INC.
Patent: WO2008/30520 A1, 2008 ;
Location in patent: Page/Page column 158 ;
WO 2008/030520 A1
反应条件
1: 76.5 percent / AlCl3 / nitromethane / 6 h / Ambient temperature
2: 59.4 percent / LiAlH4 / diethyl ether / 24 h / Heating
3: 80.3 percent / methanol / 24 h / Ambient temperature
4: 1.) n-BuLi / 1.) ether, hexane, RT, 5 min, 2.) ether, hexane, RT, 36 h
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
