二(4-甲氧基苯基)(苯基)甲醇合成路线 （共 34 条）
反应条件
thionyl chloride in n-heptane 1.) 0 deg C, 10 min, 2.) RT, 10 min, 3.) reflux, 1 h;
参考文献
Huszthy; Bradshaw; Krakowiak; Wang; Dalley
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1197 - 1207
反应条件
1: 95 percent / acetic anhydride, 40percent aq. tetrafluoroboric acid 2: 93 percent / 2,6-di-t-butyl-4-methylpyridine (DBMP) / nitromethane / 17 h / 20 °C / or pyridine, other solvents View Scheme
参考文献
Hansen, Anders S.; Thalhammer, Armin; El-Sagheer, Afaf H.; Brown, Tom; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1181 - 1184
反应条件
1: 80 °C / Cooling with ice 2: tetrafluoroboric acid / water / 0.67 h / Cooling with ice 3: lithium carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Heating View Scheme
参考文献
Hansen, Anders S.; Thalhammer, Armin; El-Sagheer, Afaf H.; Brown, Tom; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1181 - 1184
反应条件
1: 80 °C / Cooling with ice 2: tetrafluoroboric acid / water / 0.67 h / Cooling with ice 3: lithium carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Heating View Scheme
参考文献
Hansen, Anders S.; Thalhammer, Armin; El-Sagheer, Afaf H.; Brown, Tom; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1181 - 1184
反应条件
sodium hydroxide in tetrahydrofuran
0.5 h; Ambient temperature;
参考文献
Bleasdale, Christine; Ellwood, Simon B.; Golding, Bernard T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 803 - 805
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran
Reflux;
2: para-methoxybenzophenone in tetrahydrofuran
T=20°C; Reflux;
参考文献
Horn, Markus; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 25 p. 7469 - 7477
反应条件
methanesulfonic acid; phosphorus pentoxide
T=20°C; Acylation; 24 h;
参考文献
Yonezawa, Noriyuki; Hino, Tetsuo; Matsuda, Kazuhisa; Matsuki, Toshiyuki; Narushima, Daisuke; Kobayashi, Masato; Ikeda, Tomiki
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 941 - 944
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran
1 h; Heating;
2: benzoic acid ethyl ester in tetrahydrofuran
Further stages.;
参考文献
Hatano, Tsukasa; Kato, Takashi
Tetrahedron, 2008 , vol. 64, # 36 p. 8368 - 8380
反应条件
trifluoroacetic acid; dibenzoyl peroxide in 1,2-dichloro-ethane
T=50°C; 24 h;
参考文献
Kitagawa, Toshikazu; Takeuchi, Ken'ichi; Murai, Osamu; Matsui, Shin; Inoue, Takeshi; Nishimura, Makoto et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 1987 - 1996
反应条件
perchloric acid in tetrahydrofuran; water
1.) 0 deg C, 10 min, 2.) RT, 1 d;
参考文献
Huszthy; Bradshaw; Krakowiak; Wang; Dalley
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1197 - 1207
