二(4-甲氧基苯基)(苯基)甲醇合成路线 （共 34 条）
反应条件
1: N1'-DMTr-biotin methylester With sodium hydride in N,N-dimethyl-formamide; mineral oil
0.5 h; Inert atmosphereCooling with ice;
2: undec-10-enoic acid chloride With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with iceInert atmosphere; regioselective reaction;
参考文献
Pehere, Ashok D.; Abell, Andrew D.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9514 - 9518
反应条件
water in acetonitrile
T=20°C; Rate constant;
参考文献
McClelland, Robert A.; Kanagasabapathy; Banait, Narinder S.; Steenken, Steen
Journal of the American Chemical Society, 1991 , vol. 113, # 3 p. 1009 - 1014
反应条件
methanesulfonic acid; phosphorus pentoxide
T=20°C; Acylation; 24 h;
参考文献
Yonezawa, Noriyuki; Hino, Tetsuo; Matsuda, Kazuhisa; Matsuki, Toshiyuki; Narushima, Daisuke; Kobayashi, Masato; Ikeda, Tomiki
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 941 - 944
反应条件
1: N1'-DMTr-biotin methylester With sodium hydride in N,N-dimethyl-formamide; mineral oil
0.5 h; Inert atmosphereCooling with ice;
2: p-toluenesulfonyl chloride With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with iceInert atmosphere; regioselective reaction;
参考文献
Pehere, Ashok D.; Abell, Andrew D.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9514 - 9518
反应条件
trifluoroacetic acid in chloroform
T=0°C; 0.133333 h;
参考文献
Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5287 - 5290
反应条件
trifluoroacetic acid in chloroform
T=0°C; 0.133333 h;
参考文献
Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5287 - 5290
反应条件
trifluoroacetic acid in chloroform
T=0°C; 0.133333 h;
参考文献
Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5287 - 5290
反应条件
1: N1'-DMTr-biotin methylester With sodium hydride in N,N-dimethyl-formamide; mineral oil
0.5 h; Inert atmosphereCooling with ice;
2: chloroacetyl chloride With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with iceInert atmosphere; regioselective reaction;
参考文献
Pehere, Ashok D.; Abell, Andrew D.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9514 - 9518
反应条件
1: pyridine
2: pyridine / 1 h
3: 2percent trifluoroacetic acid / CHCl3 / 0.13 h / 0 °C
View Scheme
参考文献
Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5287 - 5290
反应条件
1: pyridine / 1 h
2: 2percent trifluoroacetic acid / CHCl3 / 0.13 h / 0 °C
View Scheme
参考文献
Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5287 - 5290
