4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
in pyridine
2 h; Ambient temperature;
参考文献
Uesugi; Miyashiro; Tomita; Ikehara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 51 - 60
反应条件
1.1: 93 percent / pyridine / 1.5 h / 20 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 0 °C
2.2: 1,2,4-triazole; phosphorous oxycloride / acetonitrile / -20 - 0 °C
2.3: 85 percent / aq. ammonium hydroxide / dioxane / 1 h
3.1: dimethylformamide / 22 h / 20 °C
4.1: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: pyridine / 1.5 h
2: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h
3: aq. NaOH / ethanol / 1 h / 60 °C
4: 75 percent / LiEt3BH / tetrahydrofuran / 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h
View Scheme
参考文献
Webb; Mitsuya; Broder
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1475 - 1479
反应条件
1.1: 93 percent / pyridine / 1.5 h / 20 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 0 °C
2.2: 1,2,4-triazole; phosphorous oxycloride / acetonitrile / -20 - 0 °C
2.3: 85 percent / aq. ammonium hydroxide / dioxane / 1 h
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1.1: 96 percent / 2,6-lutidine / acetonitrile / -10 - 0 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
2.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
2.3: aq. NH3 / dioxane / 25 °C
3.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
1.1: pyridine / 72 h / 20 °C
1.2: 95 percent / methanol / 0.17 h / 0 °C
2.1: 66 percent / hydrogen / Pd/C / methanol / 4 h / 20 °C
View Scheme
参考文献
Dai, Qing; Piccirilli, Joseph A.
Organic Letters, 2004 , vol. 6, # 13 p. 2169 - 2172
反应条件
2,6-dimethylpyridine in acetonitrile
T=-10 - 3°C; 1.41667 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23904 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23906 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/22765 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23378 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23380 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23381 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23385 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals Inc.
Patent: US2004/23905 A1, 2004 ;
Location in patent: Page/Page column 19 ;
Title/Abstract Full Text Show Details
Isis Pharmaceuticals, Inc.
Patent: US2004/23379 A1, 2004 ;
Location in patent: Page/Page column 19 ;
反应条件
lutidine in acetonitrile
T=-10 - -2°C; 1 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225015 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
lutidine in acetonitrile
T=-10 - 3°C; 1.5 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/236206 A1, 2003 ;
Location in patent: Page 19 ;
