4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
1: 4,4'-dimethoxytriphenylmethyl chloride; 2'-O-(2-methoxyethyl)-5-methyluridine With 2,6-dimethylpyridine in acetonitrile
T=-10 - -3°C; 1.41667 h;
2: methanol in acetonitrile
0.166667 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23384 A1, 2004 ;
Location in patent: Page/Page column 19-20 ;
反应条件
2,6-dimethylpyridine in acetonitrile
T=-15 - 3°C; 1.41667 - 1.5 h;
参考文献
Song, Quanlai; Ross, Bruce S.
Patent: US2004/158055 A1, 2004 ;
Location in patent: Page 25-27 ;
反应条件
in methanol
Heating;
参考文献
Izso, Gyoengyi; Huszthy, Peter; Lempert, Karoly; Fetter, Jozsef; Simig, Gyula; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 769 - 778
参考文献
Izso, Gyoengyi; Huszthy, Peter; Lempert, Karoly; Fetter, Jozsef; Simig, Gyula; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 769 - 778
反应条件
1: in pyridine
T=20°C; 6 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
2 h;
参考文献
Mitsui Chemicals, Inc.
Patent: US2003/229223 A1, 2003 ;
Location in patent: Page 4 ;
反应条件
1: pyridine / 16 h / 70 °C
2: sodium methylate / methanol / 16 h / 0 - 20 °C
View Scheme
参考文献
Diaz-Rodriguez, Alba; Fernandez, Susana; Sanghvi, Yogesh S.; Ferrero, Miguel; Gotor, Vicente
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 581 - 587
反应条件
1: pyridine / 5 h / Ambient temperature
2: 96 percent / diisopropylammonium-tetrazolide / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Martin
Helvetica Chimica Acta, 1995 , vol. 78, # 2 p. 486 - 504
反应条件
1: 2.5 g / pyridine / 15 h / Ambient temperature
2: 84 percent / dimethylformamide / 24 h / Ambient temperature
3: 73 percent / DBU, pyridine / 15 h / Ambient temperature
View Scheme
参考文献
He; Krawczyk; Swaminathan; Shea; Dougherty; Terhorst; Law; Griffin; Coutre; Bischofberger
Journal of medicinal chemistry, 1998 , vol. 41, # 13 p. 2234 - 2242
反应条件
pyridine
Ambient temperature;
参考文献
Chanteloup, Luc; Thuong, Nguyen T.
Tetrahedron Letters, 1994 , vol. 35, # 6 p. 877 - 880
反应条件
1: 94 percent / pyridine / CH2Cl2 / 2 h / 60 °C
2: 90 percent / DBU / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Sekine, Mitsuo; Hata, Tsujiaki
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, p. 336 - 339
