4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
1: pyridine / 16 h / 70 °C
2: sodium methylate / methanol / 16 h / 0 - 20 °C
View Scheme
参考文献
Diaz-Rodriguez, Alba; Fernandez, Susana; Sanghvi, Yogesh S.; Ferrero, Miguel; Gotor, Vicente
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 581 - 587
反应条件
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Etherification; 2 h;
参考文献
Kataoka, Masanori; Hayakawa, Yoshihiro
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6087 - 6089
反应条件
pyridine; dichloro-acetic acid; triethylamine
T=25°C; 1.5 h;
参考文献
Hayakawa, Yoshihiro; Kataoka, Masanori
Journal of the American Chemical Society, 1998 , vol. 120, # 48 p. 12395 - 12401
反应条件
1: 80 percent / pyridine / 2.5 h / 20 °C
2: 94 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine; triethylamine
3 h;
参考文献
Ti, G. S.; Gaffney, B. L.; Jones, R. A.
Journal of the American Chemical Society, 1982 , vol. 104, # 5 p. 1316 - 1319
反应条件
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Etherification; 2 h;
参考文献
Kataoka, Masanori; Hayakawa, Yoshihiro
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6087 - 6089
反应条件
1: 83 percent / pyridine / 2.5 h / 20 °C
2: 91 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Jones, Paul D.; Glass, Timothy E.
Tetrahedron, 2004 , vol. 60, # 49 p. 11057 - 11065
