4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
1: pyridine 2: NEt3, DMAP / CH2Cl2 3: 1) N-methylimidazole, POCl3, 2) iPr2NEt / 1) MeCN, r.t., 3 h, 2) MeCN, 3 h 4: 88 percent / aq.NH3 / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Nikiforov, Theo T.; Conolly, Bernard A.
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2379 - 2382
反应条件
pyridine T=0°C; 5 h;
参考文献
Wang, Qiang; Li, Yanfeng; Song, Chuanjun; Qian, Keduo; Chen, Chin-Ho; Lee, Kuo-Hsiung; Chang, Junbiao
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4053 - 4056
反应条件
pyridine T=20°C; 1.5 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232977 A1, 2003 ;
Location in patent: Page 17-18 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 5 h;
参考文献
D'Onofrio, Jennifer; De Napoli, Lorenzo; Di Fabio, Giovanni; Montesarchio, Daniela
Synlett, 2006 , # 6 p. 845 - 848
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232773 A1, 2003 ;
Location in patent: Page 16-17 ;
反应条件
1: 99 percent / aq. NaOH / tetrahydrofuran / 0.5 h / Ambient temperature 2: 95 percent / acetic anhydride, 40percent aq. tetrafluoroboric acid 3: 93 percent / 2,6-di-t-butyl-4-methylpyridine (DBMP) / nitromethane / 17 h / 20 °C / or pyridine, other solvents View Scheme
参考文献
Hansen, Anders S.; Thalhammer, Armin; El-Sagheer, Afaf H.; Brown, Tom; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1181 - 1184
反应条件
pyridine T=20°C; 12 h;
参考文献
ABBOTT LABORATORIES
Patent: US2010/69348 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
1: pyridine / 3 h / 20 °C 2: sodium methylate / methanol / 2 h / 20 °C / Reflux View Scheme
参考文献
Martinez-Montero, Saul; Fernandez, Susana; Sanghvi, Yogesh S.; Gotor, Vicente; Ferrero, Miguel
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 17 p. 5960 - 5966
参考文献
Zeidler, Joanna; Golankiewicz, Bozenna
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 1077 - 1095
反应条件
1: sodium hydroxide / tetrahydrofuran; water / 1.5 h / 20 °C 2: 80 °C / Cooling with ice 3: tetrafluoroboric acid / water / 0.67 h / Cooling with ice 4: lithium carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Heating View Scheme
参考文献
Hansen, Anders S.; Thalhammer, Armin; El-Sagheer, Afaf H.; Brown, Tom; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1181 - 1184
