4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
in pyridine T=5°C; 20 h;
参考文献
Reddy, M. P.; Farooqui, Firdous; Hanna, Naeem B.
Tetrahedron Letters, 1995 , vol. 36, # 49 p. 8929 - 8932
反应条件
1: acetic anhydride; 1-(β-D-ribofuranosyl)-4-aminopyrimidin-2-one in N,N-dimethyl-formamide T=20°C; 14 h; 2: 4,4'-dimethoxytriphenylmethyl chloride With pyridine in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
Pitsch, Stefan; Weiss, Patrick A.; Jenny, Luzi; Stutz, Alfred; Wu, Xiaolin
Helvetica Chimica Acta, 2001 , vol. 84, # 12 p. 3773 - 3795
反应条件
1: 94 percent / pyridine / CH2Cl2 / 2 h / 60 °C 2: 90 percent / DBU / acetonitrile / 2 h / 20 °C 3: 73 percent / 1H-tetrazole / acetonitrile / 1 h View Scheme
参考文献
Wagner, Thomas; Pfleiderer, Wolfgang
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1657 - 1660
反应条件
1: 4,4'-dimethoxytriphenylmethyl chloride; N4-acetylcytidine With pyridine T=20°C; Cooling with ice; 2: tert-butyldimethylsilyl chloride With silver nitrate in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
WO2010/108140 A1, ;
Page/Page column 138-139 ;
参考文献
Nucleosides, nucleotides and nucleic acids, , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: 61 percent / pyridine / 25 °C 2: 57 percent / AgNO3, pyridine / tetrahydrofuran / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 14 p. 1897 - 1900
反应条件
1: 97 percent / Et3N / pyridine / 1.5 h 2: 84 percent / (i-Pr)2EtN / CH2Cl2 / 1.) 0 deg C, 5 min; 2.) RT, 2 h View Scheme
参考文献
Kawasaki; Casper; Freier; Lesnik; Zounes; Cummins; Gonzalez; Cook
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 831 - 841
反应条件
1: 78 percent / pyridine 2: diisopropylammonium tetrazolide View Scheme
参考文献
Vu, Huynh; McCollum, Christie; Jacobson, Karen; Theisen, Pete; Vinayak, Ravi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7269 - 7272
参考文献
Reddy; Hanna, Naeem B.; Farooqui, Firdous
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1589 - 1598
反应条件
pyridine in ethyl acetate
参考文献
La Jolla Pharmaceutical Company
Patent: US5552391 A1, 1996 ;
