4,4'-双甲氧基三苯甲基氯合成路线 （共 132 条）
反应条件
pyridine T=20°C; 16 h;
参考文献
Seth, Punit P.; Vasquez, Guillermo; Allerson, Charles A.; Berdeja, Andres; Gaus, Hans; Kinberger, Garth A.; Prakash, Thazha P.; Migawa, Michael T.; Bhat, Balkrishen; Swayze, Eric E.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1569 - 1581
反应条件
1.1: pyridine / 30 h 2.1: mesyl chloride; pyridine / 0 - 20 °C 2.2: 33.5 g / sodium hydroxide; pyridine / H2O / 48 h / 20 °C View Scheme
参考文献
Kong, Jong Rock; Kim, Sang Kook; Moon, Byung Jo; Kim, Su Jeong; Kim, Byeang Hyean
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1751 - 1760
反应条件
pyridine; N-ethyl-N,N-diisopropylamine T=40°C; 3 h;
参考文献
Rosemeyer, Helmut; Seela, Frank
Helvetica Chimica Acta, 1991 , vol. 74, # 4 p. 748 - 760
参考文献
Morphy, J. Richard; Parker, David; Kataky, Ritu; Eaton, Michael A. W.; Millican, Andrew T.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990 , # 4 p. 573 - 585
反应条件
1: pyridine / 2 h / 20 °C
2: tetrahydrofuran / -8 - 0 °C
3: aq. NaOH / ethanol / 16 h / 80 °C
View Scheme
参考文献
Chambert, Stephane; Gautier-Luneau, Isabelle; Fontecave, Marc; Decout, Jean-Luc
Journal of Organic Chemistry, 2000 , vol. 65, # 1 p. 249 - 253
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
pyridine; triethylamine
T=20°C; 3 h;
参考文献
Lewdorowicz, Magdalena; Stepinski, Janusz; Kierzek, Ryszard; Jemielity, Jacek; Zuberek, Joanna; Yoffe, Yael; Shapira, Michal; Stolarski, Ryszard; Darzynkiewicz, Edward
Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 10-12 p. 1339 - 1348
反应条件
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Etherification; 2 h;
参考文献
Kataoka, Masanori; Hayakawa, Yoshihiro
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6087 - 6089
反应条件
1: 80 percent / pyridine / 2.5 h / 20 °C
2: 90 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
反应条件
1: 5-Methyl-2'-deoxycytidine; benzoic acid anhydride in DMF (N,N-dimethyl-formamide)
T=40°C; 5 h;
2: 4,4'-dimethoxytriphenylmethyl chloride With pyridine in DMF (N,N-dimethyl-formamide)
T=10°C; 15 h;
3: With sodium hydroxide; sodium hydrogencarbonate
Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: US2005/192433 A1, 2005 ;
Location in patent: Page/Page column 6 ;
