1: With chloro-trimethyl-silane; triethylamine in acetonitrile
T=-10 - 0°C;
2: With 1H-1,2,4-triazol; trichlorophosphate in acetonitrile
T=-20 - 0°C;
3: With ammonium hydroxide in 1,4-dioxane
1 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/2152 A1, 2004 ;
Location in patent: Page/Page column 17 ;
1: With triethylamine in acetonitrile
T=-10 - 0°C; 0.5 h;
2: With 1H-(1,2,3)-triazole; trichlorophosphate in acetonitrile
T=-20 - 0°C; 2 h;
3: With ammonia in 1,4-dioxane; water
参考文献
ISIS PHARMACEUTICALS, INC.
Patent: WO2003/99840 A1, 2003 ;
Location in patent: Page 218-219 ;
