3-(叔丁氧基羰基氨基)哌啶-1-羧酸苄酯合成路线 （共 6 条）
反应条件
1: With hydrogenchloride in 1,4-dioxane T=0 - 20°C; 2: With water; sodium carbonate
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art
Patent: WO2012/58645 A1, 2012 ;
Location in patent: Page/Page column 117-118 ;
WO 2012/058645 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C;
参考文献
Eisai Co., Ltd.
Patent: EP1557165 A1, 2005 ;
Location in patent: Page/Page column 88 ;
反应条件
1: With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 4 h; 2: With hydrogen; palladium on activated charcoal in ethanol T=20°C; 5 h;
参考文献
Eisai Co., Ltd.
Patent: US2004/116328 A1, 2004 ;
US 20040116328 A1
反应条件
1: With hydrogenchloride; sodium hydroxide; diphenyl phosphoryl azide; triethylamine in ethanol; water; ethyl acetate; toluene
T=0 - 20°C;
2: With diphenyl phosphoryl azide; triethylamine in tert-butyl alcohol
T=20 - 100°C; 21.5 h;
参考文献
Eisai Co., Ltd.
Patent: EP1568699 A1, 2005 ;
Location in patent: Page/Page column 41 ;
反应条件
1: benzyl chloroformate; piperidine-3-carboxylic acid ethyl ester With triethylamine in ethyl acetate; toluene
T=0°C; 0.5 h;
2: With sodium hydroxide; water in ethanol
T=20°C;
3: tert-butyl alcohol With diphenylphosphoranyl azide; triethylamine
T=20 - 100°C; 21.5 h;
参考文献
Eisai Co., Ltd.
Patent: EP1557165 A1, 2005 ;
Location in patent: Page/Page column 87 ;
反应条件
diphenyl phosphoryl azide; triethylamine
T=20 - 100°C; 21.5 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/219178 A1, 2007 ;
Location in patent: Page/Page column 48-49 ;
