N-BOC-4-甲基-4-羟基哌啶合成路线 （共 10 条）
反应条件
in tetrahydrofuran; diethyl ether T=-30 - 23°C; 12 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 41 p. 15342 - 15345
反应条件
1: in tetrahydrofuran T=-40 - 20°C; 2.16667 h; 2: With water; ammonium chloride in tetrahydrofuran T=0°C;
参考文献
WO2008/84300 A1, ;
Page/Page column 105 ;
WO 2008/084300 A1
反应条件
in diethyl ether; chloroform; water T=-78 - 20°C; 1.5 h;
参考文献
EP1762568 A1, ;
Page/Page column 49 ;
反应条件
in diethyl ether T=-25 - 20°C; 2 h; Inert atmosphere;
参考文献
WO2014/28384 A1, ;
Page/Page column 78 ;
反应条件
1: 4-methyl-piperidin-4-ol hydrochloride With sodium hydride; triethylamine in N,N-dimethyl-formamide; mineral oil T=25°C; 0.35 h; 2: di-tert-butyl dicarbonate in N,N-dimethyl-formamide; mineral oil T=25°C; 18 h;
参考文献
US2009/192156 A1, ;
Page/Page column 27-28 ;
反应条件
methylmagnesium bromide; ammonium chloride in diethyl ether
参考文献
US2002/86887 A1, ;
US 20020086887 A1
反应条件
methylmagnesium bromide in diethyl ether
参考文献
US2002/55631 A1, ;
US 20020055631 A1
反应条件
in tetrahydrofuran T=-78 - 0°C; 1 h;
参考文献
US2013/236468 A1, ;
Paragraph 0321 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
CHIESI FARMACEUTICI S.P.A.; VAN NIEL, Monique Bodil; RAY, Nicholas Charles; ALCARAZ, Lilian; PANCHAL, Terry Aaron; JENNINGS, Andrew Stephen Robert; ARMANI, Elisabetta; CRIDLAND, Andrew Peter; HURLEY, Cristopher
Patent: WO2013/83604 A1, 2013 ;
Location in patent: Page/Page column 278 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=0 - 23°C; 2 h;
参考文献
H. LUNDBECK A/S
Patent: US2011/92475 A1, 2011 ;
Location in patent: Page/Page column 19 ;
