4,5'-二甲基异补骨脂素合成路线 （共 19 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 16 h; Heatingirradiation;
参考文献
Mistry, Samir; Desai, Suresh; Rao, S. S. Madhava; Shah, Amrish
Heterocyclic Communications, 2004 , vol. 10, # 2-3 p. 145 - 150
反应条件
1: 67 percent / NBS; benzoyl peroxide / CCl4 / 16 h / Heating; irradiation 2: 69 percent / dimethylformamide / 0.92 h / Heating View Scheme
参考文献
Madhavarao; Trivedi
Pharmazie, 1991 , vol. 46, # 9 p. 644 - 646
反应条件
N,N-dimethyl-aniline
T=225°C; 24 h;
参考文献
Kaufman, Kurt D.; Hewitt, Larry E.
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 738 - 740
反应条件
N,N-dimethyl-aniline
T=220°C; 21 h;
参考文献
Mali, Raghao S.; Pandhare, Nalini A.; Sindkhedkar, Milind D.
Tetrahedron Letters, 1995 , vol. 36, # 39 p. 7109 - 7110
反应条件
Cu(acac)2*H2O; lithium chloride; palladium dichloride in water; N,N-dimethyl-formamide
T=25°C; 3 h;
参考文献
Majumdar; Mondal, Shovan; Chattopadhyay, Buddhadeb
Synthetic Communications, 2010 , vol. 40, # 14 p. 2147 - 2157
反应条件
potassium hydroxide in ethanol
1.33333 h; Heating;
参考文献
Guiotto; Rodighiero; Pastorini; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 489 - 494
反应条件
sodium hydroxide; bis(benzonitrile)palladium(II) dichloride
2a) benzene, r.t., 30 min, 2b) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Kumar, R. Jagdish; Krupadanam, G. L. David; Srimannarayana, G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1078 - 1079
反应条件
1: 89 percent / potassium carbonate / acetone / 4 h / Heating
2: 45 percent / N,N-dimethylaniline / 24 h / 225 °C
View Scheme
参考文献
Kaufman, Kurt D.; Hewitt, Larry E.
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 738 - 740
反应条件
1: 66 percent / bromine / acetic acid / 1 h / Ambient temperature
2: 39.3 percent / 4 percent KOH / ethanol / 1.33 h / Heating
View Scheme
参考文献
Guiotto; Rodighiero; Pastorini; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 489 - 494
反应条件
1: 52 percent / N,N-diethylaniline / 5 h / Heating
2: 76 percent / AcONa / 1 h / Heating
3: 66 percent / bromine / acetic acid / 1 h / Ambient temperature
4: 39.3 percent / 4 percent KOH / ethanol / 1.33 h / Heating
View Scheme
参考文献
Guiotto; Rodighiero; Pastorini; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 489 - 494
