3-(3-溴苯基)丙酸乙酯合成路线 （共 4 条）
反应条件
1: m-bromohydrocinnamic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
2 h;
2: ethanol in dichloromethane
T=-10 - 20°C; 4 h;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58581 A1, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/058581 A1
反应条件
1: m-bromohydrocinnamic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
2 h;
2: ethanol in dichloromethane
T=-10 - 25°C; 4 h;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS
Patent: WO2006/41404 A1, 2006 ;
Location in patent: Page/Page column 72-73 ;
WO 2006/041404 A1
反应条件
tributyl-amine; tetrabutyl-ammonium chloride; palladium diacetate in N,N-dimethyl-formamide
T=90°C; 1 h;
参考文献
Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta
Synlett, 2003 , # 8 p. 1133 - 1136
反应条件
tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; niobium bromide in pyridine; N,N-dimethyl-formamide
T=70°C; Electrochemical reaction;
参考文献
Condon, Sylvie; Dupre, Daniel; Falgayrac, Gilles; Nedelec, Jean-Yves
European Journal of Organic Chemistry, 2002 , # 1 p. 105 - 111
