3-(1H-吲哚-3-基)丙酸乙酯合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 0.666667 h;
参考文献
Pedras, M. Soledade C.; Sarma-Mamillapalle, Vijay K.
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 32 p. 7792 - 7798
反应条件
1: Cs2CO3 / acetonitrile 2: aq. NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Dassonville, Alexandra; Breteche, Anne; Evano, Johan; Duflos, Muriel; Le Baut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5441 - 5444
反应条件
ethanol; hydrazine T=60°C;
参考文献
NEUROSEARCH A/S
Patent: WO2009/65854 A1, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 1.) NaH / 1.) DMSO, RT, 0.5 h, 2.) DMSO, RT, 12 h 2: 6 M NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: diisobutylaluminium hydride / toluene / -78 °C 2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water 3: sodium tetrahydroborate; NiII chloride hexahydrate / methanol View Scheme
参考文献
Pedras, M. Soledade C.; Sarma-Mamillapalle, Vijay K.
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 32 p. 7792 - 7798
反应条件
sulfuric acid in water
T=0°C; Reflux;
参考文献
Pedras, M. Soledade C.; Minic, Zoran; Thongbam, Premila D.; Bhaskar, Vangala; Montaut, Sabine
Phytochemistry, 2010 , vol. 71, # 17-18 p. 1952 - 1962
反应条件
bismuth oxide perchlorate in acetonitrile
Michael addition; 0.75 h; ultrasonic irradiation;
参考文献
Mohammadpoor-Baltork, Iraj; Reza Memarian, Hamid; Reza Khosropour, Ahmad; Nikoofar, Kobra
Heterocycles, 2006 , vol. 68, # 9 p. 1837 - 1843
反应条件
thionyl chloride in ethanol
参考文献
Ciba-Geigy Corporation
Patent: US4536505 A1, 1985 ;
反应条件
1: ethanolic KOH
2: concentrated H2SO4
View Scheme
参考文献
Smith; Sogn
Journal of the American Chemical Society, 1945 , vol. 67, p. 822
反应条件
1: TEA; DMAP / acetonitrile
2: aq. LiOH / tetrahydrofuran
View Scheme
参考文献
Lee, Kyeong; Boovanahalli, Shanthaveerappa K.; Nam, Ky-Youb; Kang, Sang-Uk; Lee, Mijeoung; Phan, Jason; Wu, Li; Waugh, David S.; Zhang, Zhong-Yin; Kyoung, Tai No; Jung, Jun Lee; Burke Jr., Terrence R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4037 - 4042
