(Z)-8-十二烯-1-醇合成路线 （共 30 条）
反应条件
pyridine in dichloromethane T=20°C; 12 h; Inert atmosphere; chemoselective reaction;
参考文献
Herbert, Myles B.; Marx, Vanessa M.; Pederson, Richard L.; Grubbs, Robert H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 310 - 314
Angew. Chem., 2012 , vol. 125, # 1 p. 328 - 332,5
参考文献
Aukrust, Audun; Rongved, Pal; Skatteboel, Lars
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 4 p. 267 - 272
参考文献
Ishmuratov; Ishmuratova; Odinokov; Tolstikov
Chemistry of Natural Compounds, 1997 , vol. 33, # 1 p. 25 - 30
反应条件
C32H43N3O4Ru in tetrahydrofuran
4 h; Overall yield = 73 percent; Overall yield = 0.56 g; diastereoselective reaction;
参考文献
GRUBBS, ROBERT H.; HERBERT, MYLES B.; WICKENS, ZACHARY K.; MARX, VANESSA M.
Patent: US2013/231499 A1, 2013 ;
Location in patent: Paragraph 0193; 0194 ;
反应条件
C32H41N3O4Ru in tetrahydrofuran
T=20°C; 4 h; Inert atmosphereGlovebox; chemoselective reaction;
参考文献
Herbert, Myles B.; Marx, Vanessa M.; Pederson, Richard L.; Grubbs, Robert H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 310 - 314
Angew. Chem., 2012 , vol. 125, # 1 p. 328 - 332,5
反应条件
diisobutylaluminium hydride in diethyl ether; toluene
1.) 0 deg C, 2h, 2.) room temperature, 15h;
参考文献
Odinokov, V. N.; Akhmetova, V. R.; Khasanov, Kh. D.; Abduvakhabov, A. A.; Tolstikov, G. A.; Panasenko, A. A.
Chemistry of Natural Compounds, 1989 , vol. 25, p. 240 - 243
Khimiya Prirodnykh Soedinenii, 1989 , # 2 p. 276 - 279
反应条件
lithium aluminium tetrahydride in diethyl ether
1 h; Heating;
参考文献
Aukrust, Audun; Rongved, Pal; Skatteboel, Lars
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 4 p. 267 - 272
反应条件
1: LiAlH4 / diethyl ether
2: H2 / Lindlar catalyst / methanol
View Scheme
参考文献
Kovaleva,A.S. et al.
Journal of Organic Chemistry USSR (English Translation), 1972 , vol. 8, p. 2523 - 2527
Zhurnal Organicheskoi Khimii, 1972 , vol. 8, p. 2474 - 2479
反应条件
1: 89 percent / NH2 / tetrahydrofuran; dimethylsulfoxide
2: 1) 9-BBN, 2) H2O2, AcONa
3: 85 percent / H2 / Ni-P2
View Scheme
参考文献
Ishmuratov; Ishmuratova; Odinokov; Tolstikov
Chemistry of Natural Compounds, 1997 , vol. 33, # 1 p. 25 - 30
反应条件
1: (i) KOH, MeOH, (ii) /BRN= 1736285/
2: N2H4*H2O / bis-(2-hydroxy-ethyl) ether; methanol
3: LiAlH4
4: NH2CH2CH2NH2 / Ni catalyst / ethanol
View Scheme
参考文献
Mori; Uchida; Matsui
Tetrahedron, 1977 , vol. 33, # 4 p. 385 - 387
