3-(3-氯苯氧基)-2-氧代丙基磷酸二甲酯合成路线 （共 6 条）
反应条件
n-butyllithium in tetrahydrofuran; ethyl acetate
参考文献
Ono Pharmaceutical Company
Patent: US4065632 A1, 1977 ;
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: methyl 2-(3-chlorophenoxy)acetate in tetrahydrofuran T=-78 - 20°C; 2.5 h; Inert atmosphere;
参考文献
Mudduluru, Harikrishna; Hindupur, Rama M.; Dubey, Pramod K.; Madhavaram, Shankar; Tatini, Lakshmikumar; Subbaraju, Gottumukkala V.
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 234 - 241
反应条件
sodium hydrogencarbonate in water; acetic acid; 2-oxo-propionic acid
参考文献
Imperial Chemical Industries Limited
Patent: US4046841 A1, 1977 ;
反应条件
hydrogenchloride; sodium chloride; sodium hydrogencarbonate; phosphorous acid trimethyl ester in methanol; ethyl acetate; toluene
参考文献
Imperial Chemical Industries Limited
Patent: US4046841 A1, 1977 ;
反应条件
1: 78.4 percent / K2CO3 / acetone / 4 h / Heating 2: 4 N BuLi / 1) THF, -78 deg C, 5 min, 2) - 78 deg C, 3.5 h View Scheme
参考文献
Mudduluru, Harikrishna; Hindupur, Rama M.; Dubey, Pramod K.; Madhavaram, Shankar; Tatini, Lakshmikumar; Subbaraju, Gottumukkala V.
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 234 - 241
反应条件
sodium hydride
1.) THF, 90 min, 2.) THF, 30 min; Yield given. Multistep reaction;
参考文献
Schaaf, Thomas K.; Bindra, Jasjit S.; Eggler, James F.; Plattner, Jacob J.; Nelson, A. James; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1353 - 1359
