(2R)-1,4-二恶烷-2-甲醇合成路线 （共 8 条）
反应条件
sodium hydroxide
T=90°C; 2 h;
参考文献
Kim, Ha Young; Kuhn, Richard J.; Patkar, Chinmay; Warrier, Ranjit; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2667 - 2679
反应条件
1: 84 percent / NaOH / H2O / 2 h / 20 °C
2: 36 percent / NaOH / H2O / 2 h / 90 °C
View Scheme
参考文献
Kim, Ha Young; Kuhn, Richard J.; Patkar, Chinmay; Warrier, Ranjit; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2667 - 2679
反应条件
lithium aluminium tetrahydride; aluminium trichloride
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
sodium hydroxide
T=90°C; 1 h;
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: 95 percent / pyridine / 1 h / 90 °C
2: (R)-1-phenylethylamine / propan-2-ol
3: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: KOH / aq. ethanol
2: 95 percent / pyridine / 1 h / 90 °C
3: (R)-1-phenylethylamine / propan-2-ol
4: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: (R)-1-phenylethylamine / propan-2-ol
2: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
in dichloromethane; water
T=20°C; Large scale reaction;
参考文献
Stewart, Gavin W.; Brands, Karel M. J.; Brewer, Sarah E.; Cowden, Cameron J.; Davies, Antony J.; Edwards, John S.; Gibson, Andrew W.; Hamilton, Simon E.; Katz, Jason D.; Keen, Stephen P.; Mullens, Peter R.; Scott, Jeremy P.; Wallace, Debra J.; Wise, Christopher S.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 849 - 858
