(2S)-1,4-二恶烷-2-甲醇合成路线 （共 10 条）
反应条件
sodium hydroxide in water
T=90°C; 2 h;
参考文献
Kim, Ha Young; Kuhn, Richard J.; Patkar, Chinmay; Warrier, Ranjit; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2667 - 2679
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
1 h;
参考文献
Dinsmore, Christopher J.; Gabarda Ortega, Ana Esther; Guerin, David J.; Jewell, James P.; Katz, Jason D.; Lim, Jongwon; Machacek, Michelle R.; Otte, Ryan D.; Young, Jonathan R.
Patent: US2006/293358 A1, 2006 ;
Location in patent: Page/Page column 50 ;
US 20060293358 A1
反应条件
sodium hydroxide in water
T=20 - 90°C; 5 h;
参考文献
Rotstein, David Mark; Melville, Chris Richard
Patent: US2008/249087 A1, 2008 ;
Location in patent: Page/Page column 35 ;
US 20080249087 A1
反应条件
1: With boron trifluoride diethyl etherate in toluene
T=30 - 38°C; 0.333333 h;
2: With sodium hydroxide in water; toluene
T=16 - 20°C; 1 h;
参考文献
Bukhtiyarov, Yuri; Cacatian, Salvacion; Dillard, Lawrence Wayne; Fuchs, Klaus; Jia, Lanqi; Lala, Deepak S.; Morales-Ramos, Angel; Singh, Suresh B.; Venkatraman, Shankar; Xu, Zhenrong; Yuan, Jing; Zhao, Yi; Zheng, Yajun; Dorner-Ciossek, Cornelia; Gross, Ulrike; Heine, Niklas; Sauer, Achim
Patent: US2014/57927 A1, 2014 ;
Location in patent: Paragraph 0294; 0295 ;
反应条件
water; sodium hydroxide
T=20 - 85°C;
参考文献
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.; CHIANG, Phoebe; GHOSH, Shomir
Patent: WO2010/68863 A2, 2010 ;
Location in patent: Page/Page column 70 ;
WO 2010/068863 A2
反应条件
1: 81 percent / NaOH / H2O / 2 h / 20 °C
2: 36 percent / NaOH / H2O / 2 h / 90 °C
View Scheme
参考文献
Kim, Ha Young; Kuhn, Richard J.; Patkar, Chinmay; Warrier, Ranjit; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2667 - 2679
反应条件
sodium hydroxide
T=90°C; 1 h;
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: 95 percent / pyridine / 1 h / 90 °C
2: (R)-1-phenylethylamine / propan-2-ol
3: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: KOH / aq. ethanol
2: 95 percent / pyridine / 1 h / 90 °C
3: (R)-1-phenylethylamine / propan-2-ol
4: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
反应条件
1: (R)-1-phenylethylamine / propan-2-ol
2: aq. NaOH / 1 h / 90 °C
View Scheme
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi
Enantiomer, 2001 , vol. 6, # 5 p. 267 - 273
