1-溴-4-三氟甲氧基苯合成路线 （共 46 条）
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With methanol in tetrahydrofuran Reactivity;
参考文献
Shi, Lei; Chu, Yuanyuan; Knoechel, Paul; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2760 - 2764
反应条件
copper(l) iodide; per-6-NH2-β-CD; sodium carbonate; potassium iodide in N,N-dimethyl-formamide T=130°C; 24 h; Microwave irradiation;
参考文献
Azath, Ismail Abulkalam; Suresh, Palaniswamy; Pitchumani, Kasi
New Journal of Chemistry, 2012 , vol. 36, # 11 p. 2334 - 2339
反应条件
in N,N-dimethyl-formamide Heating / reflux;
参考文献
KALYPSYS, INC.
Patent: US2007/270434 A1, 2007 ;
Location in patent: Page/Page column 16 ;
US 20070270434 A1
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: 1-naphthyl cyanate in diethyl ether; hexane T=25°C; 1 h; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: carbon dioxide in diethyl ether; hexane T=-78°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-100°C; 2 h; 2: carbon dioxide
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane 2: carbon dioxide
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
in tetrahydrofuran; biphenyl; pentane T=-75.16°C; Inert atmosphere; Equilibrium constant;
参考文献
Gorecka-Kobylinska, Joanna; Schlosser, Manfred
Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 222 - 229
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 2 h; 2: (4-morpholinyl)methanone in tetrahydrofuran; hexane
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 83-84 ;
WO 2007/015588 A1
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=60°C; 24 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
