1-溴-4-三氟甲氧基苯合成路线 （共 46 条）
反应条件
(i) Mg, (ii) /BRN= 507100/, (iii) aq. Cr2O72-; Multistep reaction;
参考文献
DoAmaral,J.R. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 862 - 866
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: With copper(I) bromide dimethylsulfide complex in diethyl ether; hexane T=-75°C; 0.0833333 h; 3: 2-ethoxycarbonylacetyl chloride in diethyl ether; hexane T=-75°C; 2 h; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: oxirane in diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl2*4LiCl in tetrahydrofuran T=25°C; 10 h; Inert atmosphere; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=0 - 25°C; Inert atmosphere; chemospecific reaction;
参考文献
Wunderlich, Stefan H.; Kienle, Marcel; Knochel, Paul
Angewandte Chemie, International Edition, 2009 , vol. 48, # 39 p. 7256 - 7260
Angewandte Chemie, 2009 , vol. 121, # 39 p. 7392 - 7396
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: methyl iodide in diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
triethylsilane; magnesium; trifluoroacetic acid Multistep reaction;
参考文献
Olah,G.A.; Yamato,T.; Hashimoto,T.
Journal of the American Chemical Society, 1987 , vol. 109, p. 3708
反应条件
sodium formate; bis(triphenylphosphine)palladium(II) chloride in CO; N,N-dimethyl-formamide
参考文献
Bayer Aktiengesellschaft
Patent: US6462242 B1, 2002 ;
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: N,N-dimethyl-formamide in diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
iodine; magnesium in diethyl ether
参考文献
Imperial Chemical Industries PLC
Patent: US5091416 A1, 1992 ;
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: With iodine in tetrahydrofuran; diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
