1-溴-4-三氟甲氧基苯合成路线 （共 46 条）
反应条件
sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=20°C; 1 h; Heating / reflux;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2003/105853 A1, 2003 ;
Location in patent: Page 39 ;
WO 03/105853 A1
反应条件
palladium diacetate; silver nitrate
T=150°C; 48 h; Inert atmosphere;
参考文献
Hong, Wenkun; Qiu, Yatao; Yao, Zhiyi; Wang, Zhaoyang; Jiang, Sheng
Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4916 - 4919
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With Pd0(tris(tert-butyl)phosphine)2; t-Bu3P*HBr in butanone
T=70°C; 0.833333 h; Inert atmosphere;
2: potassium (phenyl)dimethylsilanololate in toluene
T=19.5 - 21.8°C; Inert atmosphere;
参考文献
Denmark, Scott E.; Smith, Russell C.; Chang, Wen-Tau T.
Tetrahedron, 2011 , vol. 67, # 24 p. 4391 - 4396
反应条件
1 Pd/C Selcat Q6; tetrabutyl ammonium fluoride; triphenylphosphine in N,N-dimethyl-formamide
T=110°C; Hiyama reaction; 6 h; Inert atmosphere;
参考文献
Komaromi, Anna; Szabo, Fruzsina; Novak, Zoltan
Tetrahedron Letters, 2010 , vol. 51, # 41 p. 5411 - 5414
反应条件
1: With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane in tetrahydrofuran
T=65°C; 2 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; pH=7;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/7658 A2, 2005 ;
Location in patent: Page 215 ;
WO 2005/007658 A2
反应条件
palladium (II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane in 1-methyl-pyrrolidin-2-one
T=150°C; 16 h; Inert atmosphere;
参考文献
Shang, Rui; Fu, Yao; Li, Jia-Bin; Zhang, Song-Lin; Guo, Qing-Xiang; Liu, Lei
Journal of the American Chemical Society, 2009 , vol. 131, p. 5738 - 5739
