1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78 - -50°C; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; methanol; hexanes; water
1: 4-hydroxytetrahydro-4H-pyran With potassium tert-butylate in tetrahydrofuran
T=20°C; 0.333333 h;
2: 3-bromo-5-fluoro-pyridine in tetrahydrofuran
T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/322803 A1, 2012 ;
Location in patent: Page/Page column 20 ;
US 20120322803 A1
