4-二甲氨基-3-硝基三氟甲苯合成路线 （共 4 条）
反应条件
in dimethyl sulfoxide T=50°C;
参考文献
MERCK PATENT GMBH
Patent: WO2004/37789 A2, 2004 ;
Location in patent: Page 311 ;
WO 2004/037789 A2
反应条件
1: N,N-dimethyl-formamide With ammonia in water T=240°C; 0.666667 h; 2: 1-fluoro-2-nitro-4-trifluoromethylbenzene in water T=30°C; 0.333333 h;
参考文献
Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in sulfolane T=180°C;
参考文献
Maggini, Michele; Passudetti, Margherita; Gonzales-Trueba, Guadalupe; Prato, Maurizio; Quintily, Ugo; Scorrano, Gianfranco
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6406 - 6411
反应条件
hydrogen; 5-palladium/activated carbon in methanol T=20°C;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 221-222 ;
WO 2005/075425 A2
