(三甲基硅基)乙酸乙酯合成路线 （共 118 条）
反应条件
LiN(Cy)2
1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 25 deg C, 4.5 h; Yield given. Multistep reaction;
参考文献
Patel; Vyas; Pandey; Tavares; Fernandes
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1935 - 1940
反应条件
1: LiAlH4 / diethyl ether / Heating
2: (i) (COCl)2, (ii) /BRN= 1732034/, Py
View Scheme
参考文献
Gerlach,H.
Helvetica Chimica Acta, 1977 , vol. 60, p. 3039 - 3044
反应条件
lithium diisopropyl amide
1.) -78 deg C, 3 h; 2.) RT, 1.5 h;
参考文献
Matsuda, Isamu
Journal of Organometallic Chemistry, 1987 , vol. 321, p. 307 - 316
反应条件
1: trimethylsilyl acetic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: tert-butyldimethylsilyl chloride in tetrahydrofuran
T=-78°C; Further stages.;
参考文献
Michida, Makoto; Mukaiyama, Teruaki
Chemistry Letters, 2008 , vol. 37, # 7 p. 704 - 705
反应条件
copper(I) bromide in tetrachloromethane
参考文献
Kovalenko, S. V.; Artamkina, G. A.; Beletskaya, I. P.; Reutov, O. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 12 p. 2668
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 12 p. 2869 - 2870
反应条件
in N,N-dimethyl-formamide
170°C, 14 h;;
参考文献
Gmelin Handbook: Sn: Org.Verb.2, 1.1.2.5.2, page 276 - 305
Full Text Show Details
Pereyre, M.; Bellegarde, B.; Valade, J.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1967 , vol. 265, p. 939 - 941
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: nickel(II) bromide, n-BuLi / tetrahydrofuran / 1) -78 degC, 5 min, 2) r.t.
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With 1,2-dibromo-1,1,2,2-tetrafluoroethane in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
参考文献
Shindo, Mitsuru; Sato, Yusuke; Koretsune, Ryoko; Yoshikawa, Takashi; Matsumoto, Kenji; Itoh, Kotaro; Shishido, Kozo
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 4 p. 477 - 478
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: 42 percent / nickel(II) bromide, n-BuLi / tetrahydrofuran / -78 - 25 °C
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: nickel(II) bromide, n-BuLi / tetrahydrofuran / -78 - 25 °C
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
