(三甲基硅基)乙酸乙酯合成路线 （共 118 条）
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: nickel(II) bromide, n-BuLi / tetrahydrofuran / -78 - 25 °C
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: nickel(II) bromide, n-BuLi / tetrahydrofuran / 1) -78 degC, 5 min, 2) r.t.
3: 1.) diisopropylamine, n-BuLi / 1.) THF, 45 min, -78 deg C
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
反应条件
1: diisopropylamine, n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: nickel(II) bromide, n-BuLi / tetrahydrofuran / -78 - 25 °C
View Scheme
参考文献
Albaugh-Robertson, Pamela; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5288 - 5302
反应条件
tetrabutyl ammonium fluoride
3 h; Ambient temperature;
参考文献
Nakamura, Eiichi; Hashimoto, Koichi; Kuwajima, Isao
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 3 p. 805 - 808
反应条件
cesium fluoride in dimethyl sulfoxide
1.) room temperature, 35 min, 2.) 100 deg C, 1 h;
参考文献
Bellassoued, Moncef; Ozanne, Nicolas
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6582 - 6584
反应条件
lithium diisopropyl amide
1.) THF, hexane, -78 deg C, 1 h, 2.) a) from -78 deg C to room temp., 1 h, b) room temp., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tsuge, Otohiko; Sone, Kazuhiro; Urano, Satoshi; Matsuda, Koyo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5171 - 5177
反应条件
LiN(Cy)2
1) -78 deg C, THF, 40 min, 2) a) -78 deg C, THF, 1h, b) room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Shimizu, Makoto; Ando, Ryoichi; Kuwajima, Isao
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1230 - 1238
反应条件
tetrabutyl ammonium fluoride in pentane
1) -25 deg C, 10 min, 2) to r.t., 1 h; Yield given. Yields of byproduct given;
参考文献
Banthorpe; Ireland
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 3 p. 279 - 282
反应条件
(i) <nBu4N>F, (ii) /BRN= 471223/, <nBu4N>F; Multistep reaction;
参考文献
Noyori,R. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 4 p. 1265 - 1267
反应条件
tetrabutyl ammonium fluoride
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nakamura, Eiichi; Shimizu, Makoto; Kuwajima, Isao; Sakata, J.; Yokoyama, K.; Noyori, R.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 932 - 945
