3-(4-甲基苯基)-3-苯丙酸合成路线 （共 12 条）
参考文献
Karsten
Chemische Berichte, 1893 , vol. 26, p. 1579
参考文献
Chemische Berichte, , vol. 26, p. 1579
反应条件
water; potassium hydroxide in methanol
3 h; Reflux;
参考文献
Prediger, Patricia; Da Silva, Allan Ribeiro; Correia, Carlos Roque Duarte
Tetrahedron, 2014 , vol. 70, # 20 p. 3333 - 3341
参考文献
v. Braun; Manz; Reinsch
Justus Liebigs Annalen der Chemie, 1929 , vol. 468, p. 288
反应条件
1: Behandeln des Reaktionsprodukts mit wss. Natriumcarbonat-Loesung
2: ethanol; palladium/barium sulfate / Hydrogenation
View Scheme
参考文献
Bergmann et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1612,1614
反应条件
1.1: NaH; NaI / dimethylformamide
1.2: dimethylformamide / 38 h / 60 - 90 °C
2.1: aq. KOH / ethanol / 12 h / Heating
3.1: 0.17 h / 180 °C
View Scheme
参考文献
Elz, Sigurd; Kramer, Kai; Leschke, Christian; Schunack, Walter
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 41 - 52
反应条件
1: aq. KOH / ethanol / 12 h / Heating
2: 0.17 h / 180 °C
View Scheme
参考文献
Elz, Sigurd; Kramer, Kai; Leschke, Christian; Schunack, Walter
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 41 - 52
反应条件
T=180°C; Decarboxylation; 0.166667 h;
参考文献
Elz, Sigurd; Kramer, Kai; Leschke, Christian; Schunack, Walter
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 41 - 52
反应条件
1: zinc
3: sodium amalgam
View Scheme
参考文献
v. Braun; Manz; Reinsch
Justus Liebigs Annalen der Chemie, 1929 , vol. 468, p. 288
反应条件
2: sodium amalgam
View Scheme
参考文献
v. Braun; Manz; Reinsch
Justus Liebigs Annalen der Chemie, 1929 , vol. 468, p. 288
