3'-O-(叔丁基二甲基硅烷基)胸苷合成路线 （共 31 条）
反应条件
pyridinium p-toluenesulfonate in methanol
T=20°C;
参考文献
Montevecchi, Pier Carlo; Manetto, Antonio; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Tetrahedron, 2004 , vol. 60, # 19 p. 4303 - 4308
反应条件
1: imidazole / dimethylformamide / 3 h / Ambient temperature
2: 80percent acetic acid / 3 h / Ambient temperature
View Scheme
参考文献
Breiner; Rose; Dunn; MacDiarmid; Bardos
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2596 - 2602
反应条件
1: imidazole / dimethylformamide
2: 95 percent / NH3 / methanol / 24 h
View Scheme
参考文献
Cameron, Melissa A.; Cush, Sarah B.; Hammer, Robert P.
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9065 - 9069
反应条件
1: 95 percent / pyridine
2: 82 percent / 80percent acetic acid
View Scheme
参考文献
Zhao, Zhengyun; Caruthers, Marvin H.
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6239 - 6242
参考文献
Gilead Sciences, Inc.
Patent: US5672697 A1, 1997 ;
反应条件
1: 93 percent / pyridine; DBU / 2.5 h / 20 °C
2: iodine; pyridine-d5; D2O
View Scheme
参考文献
Utagawa, Eri; Seio, Kohji; Sekine, Mitsuo
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 927 - 929
反应条件
copper(II) sulfate in xylene
Heating;
参考文献
Cabral, Nadia L. D.; Thiessen, Luciano Hoeltgebaum; Doboszewski, Bogdan
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 8 p. 931 - 948
反应条件
acetic acid
3 h; Ambient temperature; Yield given;
参考文献
Breiner; Rose; Dunn; MacDiarmid; Bardos
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2596 - 2602
参考文献
Angeloff; Dubey; Pratviel; Bernadou; Meunier
Chemical Research in Toxicology, 2001 , vol. 14, # 10 p. 1413 - 1420
反应条件
pyridine; iodine; water-d2
参考文献
Utagawa, Eri; Sekine, Mitsuo; Seio, Kohji
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7668 - 7677
