4-碘-1H-吡咯-2-羧酸甲酯合成路线 （共 9 条）
反应条件
methanol; sodium T=0 - 20°C; 2.5 h;
参考文献
Wyeth
Patent: US2007/4786 A1, 2007 ;
Location in patent: Page/Page column 42-43 ;
US 20070004786 A1
反应条件
indium trifluoromethanesulfonate; N-iodo-succinimide in acetonitrile T=0 - 23°C; 6 h; Inert atmosphereDarkness;
参考文献
Zhou, Cong-Ying; Li, Jing; Peddibhotla, Satyamaheshwar; Romo, Daniel
Organic Letters, 2010 , vol. 12, # 9 p. 2104 - 2107
参考文献
VERTEX PHARMACEUTICALS, INCORPORATED
Patent: WO2005/113541 A1, 2005 ;
Location in patent: Paragraph 0089 ;
WO 2005/113541 A1
参考文献
Smith, Jason A.; Ng, Sarah; White, Jonathon
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 12 p. 2477 - 2482
反应条件
1: I2, AgOOCCF3 2: MeONa View Scheme
参考文献
Volz; Holzbecher
Angewandte Chemie - International Edition in English, 1997 , vol. 36, # 13-14 p. 1442 - 1445
反应条件
copper; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=18°C; Ullmann cross-coupling reaction; 18 h; ultrasonication;
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 2 p. 296 - 305
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C;
参考文献
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.
Patent: EP2236500 A1, 2010 ;
Location in patent: Page/Page column 81 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=20°C; 16 h;
参考文献
VERTEX PHARMACEUTICALS, INCORPORATED
Patent: WO2005/113541 A1, 2005 ;
Location in patent: Paragraph 0089 ;
WO 2005/113541 A1
反应条件
in N,N-dimethyl-formamide
参考文献
C.I.R.D. Galderma
Patent: US5723499 A1, 1998 ;
