3,4-二氯-N-甲基苯胺合成路线 （共 9 条）
反应条件
sodium hydride; triethylamine in dichloromethane T=20°C;
参考文献
AMERSHAM BIOSCIENCES AB
Patent: WO2004/39765 A1, 2004 ;
Location in patent: Page 23-24 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Ambient temperature;
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Queener, Sherry F.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2615 - 2620
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating / reflux;
参考文献
AMERSHAM BIOSCIENCES AB
Patent: WO2004/39765 A1, 2004 ;
Location in patent: Page 24 ;
反应条件
1: 98 percent / 0.5 h / Heating 2: 90 percent / LiAlH4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Queener, Sherry F.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2615 - 2620
反应条件
sodium hydroxide in methanol other reagents: 1.) 0.1 mol/l H2SO4 in MeOH, 2.) H2O/MeOH; Product distribution;
参考文献
Gober; Franke; Petzold
Pharmazie, 1983 , vol. 38, # 7 p. 452 - 455
反应条件
sodium hydroxide in methanol other reagents: 1.) 0.1 mol/l H2SO4 in MeOH, 2.) H2O/MeOH; Product distribution;
参考文献
Gober; Franke; Petzold
Pharmazie, 1983 , vol. 38, # 7 p. 452 - 455
反应条件
hydrogenchloride; sodium hydrogencarbonate; pyridine in toluene
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; TOYO JOZO CO., LTD.
Patent: EP200134 B1, 1991 ;
反应条件
in anhydrous xylene T=120 - 150°C; Inert atmosphere;
参考文献
Chan, Wai-Wing; Kwong, Tsz-Lung; Yu, Wing-Yiu
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 18 p. 3749 - 3755
反应条件
hydrogenchloride; potassium hydroxide in water; toluene
参考文献
Duphar International Research B.V.
Patent: US4286983 A1, 1981 ;
