2-甲氧基-3-硝基苯甲酸合成路线 （共 16 条）
参考文献
Stoermer
Chemische Berichte, 1911 , vol. 44, p. 644
Chemische Berichte, 1909 , vol. 42, p. 4866
反应条件
1: sulfuric acid; silver sulphate; iodine / 48 h / 20 °C / |Darkness 2: AlCl3, aluminium chloride; diethyl-sulphide / dichloromethane / 48 h / 40 °C View Scheme
参考文献
Jabri, Salman Y.; Overman, Larry E.
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8766 - 8788
反应条件
sodium hydroxide in methanol
T=50°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
Location in patent: Paragraph 00211 ;
反应条件
nitric acid
T=5 - 10°C; 2 h; Yield given;
参考文献
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
2.1: sodium hydroxide / methanol; water / 2 h / |Reflux
2.2: pH 1
View Scheme
参考文献
Sun, Chang; Ren, Changliang; Wei, Yuchen; Qin, Bo; Zeng, Huaqiang
Chemical Communications, 2013 , vol. 49, # 46 p. 5307 - 5309
反应条件
sulfuric acid; nitric acid; acetic anhydride
T=-8 - -5°C;
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1922 , vol. 121, p. 1656
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2: sodium hydroxide / water; methanol / 0.25 h / 75 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
反应条件
permanganate(VII) ion; acetone
参考文献
Stoermer
Chemische Berichte, 1911 , vol. 44, p. 644
Chemische Berichte, 1909 , vol. 42, p. 4866
反应条件
alkaline permanganate
参考文献
Simonsen; Rau
Journal of the Chemical Society, 1917 , vol. 111, p. 232
反应条件
potassium carbonate; xylene
参考文献
Shah; Bhatt; Kanga
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155,157
